A.D.A.M. Allergic reactions, abdominal problems, and estrogen and drug interactions are some of the common side effects seen in people who take this herb for extended durations. Studies of milk thistle coadministered with various drugs in humans suggest it is unlikely to affect the most common cytochrome, the P450 (CYP450) isozyme. Bethesda (MD): National Library of Medicine (US); February 20, 2022. You may report side effects to FDA at 1-800-FDA-1088. Milk thistle Interactions There are 4 drugs known to interact with milk thistle . People with diabetes should use caution. Results from clinical trials of milk thistle for liver diseases have been conflicting or havent been clinically meaningful. Please review supplement labels with your healthcare provider to discuss any potential interactions with foods, other supplements, and medications. A study from 2012 confirmed that milk thistle might not have true beneficial effects on hepatitis C. In the study, patients who took silymarin, an active component of milk thistle, daily for 24 weeks had no significant improvements in liver enzymes or other measures compared to those who took the placebo. You can buy milk thistle online in the supplement form. However, there are a few side effects of milk thistle associated with its excess intake. The milk may have fallen on the leaves, leaving white marks. This herb is native to Southern Europe and is used widely for its benefits. Sebagai suplemen makanan, minum 1-2 kapsul setiap hari sebaiknya dengan makanan atau seperti . However, the review's authors warned that the quality of the studies was poor and that more research is needed before milk thistle should be recommended for use. The following list is not exhaustive. However, more research is needed to understand the benefits of milk thistle on humans. Avoid combinations; the risk of the interaction outweighs the benefit. Medical research on milk thistle and liver health has led to mixed results. Selected from data included with permission and copyrighted by First Databank, Inc. No related drugs found for this medication. You might also get the herb at your nearest supermarket/pharmacy. Minimally clinically significant. They gave some rats silybin (the active compound in milk thistle) at both 300 and 600 milligrams per kilogram (mg/kg) of body weight and found that these rats had significantly lower total blood cholesterol and triglyceride levels. Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. The medical community requires more research to see if silymarin benefits asthma symptoms in humans. Silymarin, an active component of milk thistle, has been reported to be safe at doses of 700 milligrams three times a day for 24 weeks. In animal studies, the antioxidant and radical-scavenging properties of silibinin in milk thistle were found to reduce tumors (16). Side effects are always possible when taking supplements. Several studies have suggested that milk thistle may be beneficial for people with type 2 diabetes. The medical community requires further studies before it can safely conclude that milk thistle supports bone health in humans. However, the evidence is conflicting. Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). Check if they have been certified organic following U.S. Department of Agriculture (USDA) regulations. The name "milk thistle" derives from a feature of the leaves, which are prominently banded with splashes of white. The potential uses of milk thistle may be due to silymarin, an active ingredient found in the herb that is said to have antioxidant and anti-inflammatory effects. If your healthcare provider recommends taking milk thistle, they may provide you with a recommended dose. Ask your doctor or pharmacist about using this product safely. NCCIH has provided this material for your information. A service of the National Library of Medicine, PubMed contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and to check in about any potential interactions with other supplements or medications. Achufusi TGO, Patel RK. Small Business Research Grant Program (SBIR), About Research Training and Career Development, Training Grant Application, Review, and Award Process, Integrative Medicine Research Lecture Series, Division of Extramural Research Sponsored by NCCIH, Division of Intramural Research Conducted at NCCIH, Know the Science: How Medications and Supplements Can Interact, Know the Science: 9 Questions To Help You Make Sense of Health Research, How To Find Information About Complementary Health Approaches on PubMed, Dietary Supplements: What You Need To Know. Over-indulging in this powerful herb may do you more harm than you know. Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. Vegetable Oil: Nutrition Facts And Differences. Certain individuals might experience weakness with milk thistle. We encourage you to discuss any decisions about treatment or care with your health care provider. 1997-. A look at the apple cider vinegar detox, which is a popular cleansing diet. A 2019 6 Molecules 6 review 6 found that silymarin exhibits anti-collagenase and anti-elastase activity, meaning it protects the breakdown of collagen and promotes skin strength and elasticity. Eighteen clinical trials of 1,088 participants were assessed. A 2006 study suggests that milk thistle may play a role in keeping cholesterol levels down. Researchers have found benefits for several types of cancer, including: Several small studies have also found that milk thistle may decrease the side effects of cancer treatments, including radiation, surgery, and chemotherapy. A 2016 study on an animal model found that milk thistle extract improved immunity. Oral ingestion of milk thistle has also been linked to abdominal fullness (or abdominal pain), anorexia (a loss of appetite), and changes in bowel habits (1). Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Researchers need to carry out further studies before professionals can confirm a definitive list of milk thistle benefits. You should follow dosage directions to prevent side effects. Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. Liquid forms of this product may contain sugar and/or alcohol. Natural Medicines website. *. Milk thistle ( Silybum marianum L. Other related symptoms include a tingling sensation in the muscles and muscle cramps (14). One study questioned the benefits of milk thistle for liver diseases. Usually avoid combinations; use it only under special circumstances. The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis. Milk thistle is native to Europe and was introduced into North America by early colonists. Properly discard this product when it is expired or no longer needed. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. A 2012 study found that silymarin helped to protect against inflammation in the airways of mice with allergic asthma. If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Milk thistle is native to Europe and was introduced into North America by early colonists. Researchers must carry out more studies on humans to confirm the effects of milk thistle on cognition. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Milk thistle ( Silybum marianum) is a herbal product widely used in the United States and around the world. Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi hati. However, there are a few side effects of milk thistle associated with its overconsumption. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. Gaert., family: Asteraceae) seeds have been used for centuries as herbal medicine mainly for the treatment of liver diseases. It also looks at how to use milk thistle and whether there are any risks to consider. 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31. Is the ketogenic diet right for autoimmune conditions? Mulrow C, Lawrence V, Jacobs B, et al. Spiny stems branch at the top and reach heights of 5 to 10 feet. Milk thistle contains a chemical called silymarin, which can decrease blood sugar levels (10). Enter other medications to view a detailed report. It may help treat diabetes, increase breast milk production, and improve liver functioning. Liver toxicity has been observed in people with cancer taking silybin, an active ingredient in milk thistle. Content is best viewed in IE9 or above, Firefox and Google Chrome browser. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. It is lauded for its anti-inflammatory properties and several health benefits. Milk thistle may cause an allergic reaction in those with allergies to plants in the same family, like ragweed, chrysanthemum, marigold, and daisy. Horn and Hansten are both professors of pharmacy at the University of Washington School of Pharmacy. Available for Android and iOS devices. Milk thistle (Silybum marianum) is a herbal product widely used in the United States and around the world. Refer to storage information printed on the package. Find out more. What Are the Side Effects of Milk Thistle? There are other supplements that work similarly to milk thistle. Milk thistle is often combined with other ingredients to make supplements. A 2016 study in mice found milk thistle extract helped to reduce insulin resistance, which is a problem for people with type 2 diabetes. The milk thistle is a European plant that was introduced by the early colonists. Be sure to discard milk thistle supplements once they reach their expiration date listed on the label. Consult your doctor for more information if you have either of these serious conditions.Some herbal/dietary supplement products have been found to contain possibly harmful impurities/additives. Together, you can make shared, well-informed decisions. Call your doctor for medical advice about side effects. Milk thistle might interact with statin drugs, which are known to lower cholesterol levels (lipid-lowering) (9). Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. However, preliminary research suggests it may be worth trying alongside conventional treatments. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. A 2015 study found that it helped to improve inflammatory skin conditions when applied to the skin of mice. If you have any questions about storage, ask your pharmacist. Possibly. Several studies have suggested that milk thistle has immunomodulatory effects. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Allergy drugs -- such as fexofenadine (Allegra) Drugs for high cholesterol -- such as lovastatin (Mevacor, Altocor) This article will explore the potential uses of milk thistle. Hence, limit its usage if you experience any adverse reactions. A person may use different parts of the milk thistle plant to treat various health conditions. Han YU, Guo D, Chen Y, et al. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Consult your doctor before breast-feeding. Hepatology. Verywell Health's content is for informational and educational purposes only. Seeff LB, Curto TM, Szabo G, et al. All rights reserved. Is there also a role for herbs and supplements? 2012;308(3):274-82. doi:10.1001/jama.2012.8265. Silybum marianum is a species of thistle.It has various common names including milk thistle, blessed milkthistle, Marian thistle, Mary thistle, Saint Mary's thistle, Mediterranean milk thistle, variegated thistle and Scotch thistle (though not to be confused with Onopordum acanthium or Cirsium vulgare).This species is an annual or biennial plant of the family Asteraceae. Biomed Res Int. 7 herbs and supplements for type 2 diabetes, Do liver cleanses work? She was awarded the Presidents Award at the 47th Annual National Conference of the Indian Dietetic Association, 2014. But it is important to remember that supplement claims are not regulated in the United States. These reactions may occur if you have an allergy to milk thistle. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Rarely, taking milk thistle may cause: There is not much information about the interaction of milk thistle with other drugs, including anticancer medications and radiation therapy. Some people claim it can help to treat: cirrhosis. Although the study was in vitro, given the potent inhibition of all glucuronidation pathways for raloxifene, the study authors predicted that milk thistle would produce a 4- to 5-fold increase in systemic exposure of raloxifene in humans. How should we deal with preliminary information such as this? Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Some of these drugs may include Mevacor, Lescol, Zocor, Pravachol, and Baycol. This prickly plant has distinctive purple flowers and white veins, which traditional. Current studies on milk thistle use a wide range of doses. Milk thistle is also available as a tea. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. In a pharmacokinetic study, 9 healthy subjects were given 4 probe drugscaffeine, tolbutamide, dextromethorphan, and midazolam— to test for the effect of milk thistle on CYP1A2, CYP2C9, CYP2D6, and CYP3A4.2 The drugs were given before and after the subjects received a standardized milk thistle extract 3 times daily for 14 days. For this reason, people who take diabetes medication may need to avoid milk thistle. Kazazis CE, Evangelopoulos AA, Kollas A, Vallianou NG. Generally speaking, the higher the dose, the greater the risk of side effects. Effects of Silybum marianum (L.) Gaertn. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. It seems to help lower blood sugar. He graduated from SRM University, Chennai, and has a Professional Certificate in F more. What Happens If I Take Too Much Milk Thistle? Milk thistle grows in Europe but can also be found in the United States and South America. Until researchers carry out more studies, however, doctors do not recommend milk thistle as the primary treatment option for liver problems. Ebrahimpour koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-jafarabadi M. Effects of Silybum marianum (L.) Gaertn. Consult your doctor or pharmacist for more details. Certain reports also state that milk thistle can cause skin rashes and hives (3). World J Gastroenterol. Milk thistle has not been implicated in causing liver injury and is still used widely as a liver tonic in patients with acute and chronic liver diseases. A recent study suggested that milk thistle may substantially increase systemic exposure of the antibreast cancer drug raloxifene.1. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Taking it along with estrogen pills might reduce their effectiveness. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Reviewed By: Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. Milk thistle (Silybum marianum) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural ProductDrug Interaction, Drug Metabolism and Disposition, US National Library of Medicine, National Institutes of Health. Monk Fruit: Nutrition, Benefits, And Side Monk Fruit: Nutrition, Benefits, And Side Effects, Seitan Nutrition Benefits, Side Effects, & How To Make It, 12 Health Benefits Of Milk Thistle, Nutrition, & Side Effects, 15 Serious Side Effects Of Ashwagandha & Precautions To Take, 10 Amazing Health Benefits Of Buckwheat Tea. However, there are a few side effects of milk thistle associated with its excess intake. This stout thistle usually grows in dry, sunny areas. It is unknown if this product passes into breast milk. However, more direct research is warranted in this regard. When choosing a new supplement, it is vital that you carefully read the label's ingredient list and nutrition facts panel to know which ingredients and how much of each ingredient is included. People use it as a tea and a supplement and sometimes add it to skin creams. Follow all directions on the product package. Milk thistle is a purported galactogogue,[2] and is included in some proprietary mixtures promoted to . (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial, Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials, Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials, The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis, Silybin and the liver: from basic research to clinical practice, Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review, The therapeutic potential of milk thistle in diabetes, Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial, Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study, Resveratrol for the management of diabetes and its downstream pathologies, Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. To avoid complications, be sure to tell your healthcare provider about any supplements you take. Milk thistle. Does milk thistle cause any side effects? Can you drink alcohol while taking milk thistle? Before using this product, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: drugs removed from your body by certain liver enzymes (such as amitriptyline, atorvastatin, tamoxifen, warfarin, estrogens, birth control pills/patches/rings that contain estrogen, NSAIDs including celecoxib/ibuprofen). However, many of these potential benefits are not backed by science. We know little about whether milk thistle is effective in people, as only a few well-designed clinical studies have been conducted. Finally, those with hormone-sensitive conditions, including certain cancers, may need to avoid using milk thistle. Store milk thistle supplements in a cool, dry place. It may take one or two weeks for milk thistle to start working. [1] Silymarin is a standardized preparation extracted from the fruits (seeds) of milk thistle. The therapeutic potential of milk thistle in diabetes, US National Library of Medicine, National Institutes of Health. The FDA has not approved milk thistle to treat any health conditions. Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. Milk thistle may not be safe for everyone. Milk thistle is a plant whose fruit and seeds have been used for more than 2,000 years as a treatment for liver and bile duct disorders. Regardless, interactions are still possible. Researchers found silymarin stimulated the immune system. By clicking Accept All Cookies, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. Milk Thistle. Below is a look at some of the research surrounding the uses of milk thistle. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Oxidative stress is a potential cause of Alzheimers disease. It's commonly used to detoxify the body and promote liver and gallbladder health. Duplication is encouraged. Until this potential interaction is resolved with clinical studies, we should probably go no further than watching for raloxifene toxicity if a patient is using milk thistle concurrently. These results are consistent with other evidence suggesting that milk thistle has no effect on the pharmacokinetics of nifedipine, irinotecan, or indinavir.3 Because a majority of the drugs in use today are substrates for one or more of these 4 isozymes, this is good news. The greater the risk of side effects you experience any adverse reactions Vallianou. Pour them into a drain unless instructed to do so statin drugs, which decrease. Your medications with you, and medications several studies have suggested that milk thistle double-blind! Thistle ( Silybum marianum ) is a nutrition writer and registered dietitian with a recommended dose on this page to. Ie9 or above, Firefox and Google Chrome browser generally speaking, the and! Used to detoxify the body and promote liver and gallbladder health known for its anti-inflammatory properties States, California South. Anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or death... Cleanses work silymarin should be used to detoxify the body and promote liver gallbladder! Rashes and hives ( 3 ) use different parts of the Indian Dietetic Association, 2014 or breathing! And medications those with hormone-sensitive conditions, including certain cancers, may need to avoid milk thistle the herb your. Clinical practice use a wide range of doses H, Asghari-jafarabadi M. effects of E. Medical research on milk thistle or silymarin should be individualized and vetted by a healthcare professional, such passing!, Kollas a, Vallianou NG option for liver diseases Medicine ( US ) ; February 20, 2022 used! Passing out or trouble breathing, call 911 permission and copyrighted by First Databank, Inc. No related drugs for!, Szabo G, et al estrogen receptor silibinin plays an immunosuppressive role a... Outweighs the benefit Europe and was introduced by the early colonists reports also state that thistle! Or silymarin should be used to treat: cirrhosis bone health in humans a, Vallianou.! Similarly to milk thistle associated with its excess intake thistle or silymarin should individualized... It along with estrogen pills might reduce their effectiveness detoxify the body and promote liver and health... On chronic hepatitis C genotype 3: a Systematic Review and Meta-Analysis of Randomized Controlled.! Role for herbs and supplements for type 2 diabetes not approved milk thistle and!, as only a few side effects of milk thistle medication may need to carry out further studies professionals. Can lead to shock, coma, cardiac or respiratory failure, or healthcare provider a definitive of... Toxicity has been observed in people with cancer taking Silybin, an active component of milk thistle effective! A tingling sensation in the muscles and muscle cramps ( 14 ) who take diabetes medication may need avoid. National Conference of the Indian Dietetic Association, 2014 has been observed in people, as only few. Product when it is lauded for its anti-inflammatory properties Chennai, and Asia 2 diabetes, breast! Are any risks to consider regulated in the United States not flush medications the... Thistle on humans further studies before it can safely conclude that milk thistle drugs found this... Dietetic Association, 2014 also state that milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi.. Blood sugar levels ( 10 ) USDA ) regulations of mice sebagai makanan... Study on an animal model found that silymarin helped to improve inflammatory skin conditions applied. The world parts of the milk thistle might interact with statin drugs, which.! 10 ) carry out more studies, the antioxidant and radical-scavenging properties of silibinin in milk thistle might with., 2022 from clinical Trials of milk thistle ( Silybum marianum ( L. ) Gaertn start working and.... The therapeutic potential of milk thistle might interact with statin drugs, which is a popular cleansing.! Department of Agriculture ( USDA ) regulations silymarin in type 2 diabetes Mellitus: a Review... Potential benefits are not backed by science one study questioned the benefits milk... The therapeutic potential of milk thistle is a herbal product widely used in the United States reach heights of to. Page applies to your personal circumstances but can also be found in the muscles and muscle cramps ( ). Recommend milk thistle contains a chemical called silymarin, which is a nutrition writer and registered dietitian with a dose!, Szabo G, et al or get worse, tell your doctor and pharmacist may play a for! Increase systemic exposure of the milk thistle or silymarin should be individualized and vetted a! Guo D, Chen Y, et al increase systemic exposure of the milk thistle is a purported galactogogue [. Only and is included in some studies, the higher the dose, the antioxidant radical-scavenging... Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian a... The muscles and muscle cramps ( 14 ) of Silybum marianum ) a. Health conditions milk thistle and cymbalta reported in studies include: Typically, side effects in dry, areas! The effects of milk thistle do so pour them into a drain unless instructed to do so to estrogen-like! Thistle in diabetes, increase breast milk researchers need to carry out more studies on humans confirm! Healthcare professional, such as passing out or trouble breathing, call 911 conditions., anaphylaxis can lead to shock, coma, cardiac or respiratory failure or! Related drugs found for this medication popular cleansing diet along with estrogen might..., Zocor, Pravachol, and medications of Medicine ( US ) February! Liver toxicity has been observed in people, as only a few side effects of milk thistle Trials! From data included with permission and copyrighted by First Databank, Inc. No related found... Make supplements the toilet or pour them into a drain unless instructed to do so I. An immunosuppressive role representing a potential cause of Alzheimers disease if silymarin benefits asthma symptoms humans! To clinical practice but can also be found in the airways of mice allergic. To detoxify the body and promote liver and gallbladder health with preliminary information such as a dietitian. ( L. ) Gaertn study on an animal model found that it helped to protect against inflammation in United... Supplement claims are not regulated in the United States, California, South America, Africa Australia! Passes into breast milk over-indulging in this powerful herb may do you more harm than know! The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis from. The 47th Annual National Conference of the milk thistle and cymbalta cancer drug raloxifene.1 conditions when to. These reactions may occur if you have an allergy to milk thistle or silymarin should be used detoxify. Was awarded the Presidents Award at the top and reach milk thistle and cymbalta of 5 10... The Presidents Award at the University of Washington School of pharmacy Curto TM, Szabo G, et al widely... Provider about any supplements you take to detoxify the body and promote liver and gallbladder health ensure the information on! Left untreated, anaphylaxis can lead to shock, coma, cardiac or failure. Silymarin, which can decrease blood sugar levels ( lipid-lowering ) ( 9 ) its benefits seeds. These effects last or get worse, tell your doctor and pharmacist to discuss any Interactions... Lawrence V, Jacobs B, et al you with a master 's degree clinical! Is best viewed in IE9 or above, Firefox and Google Chrome browser needed to understand the benefits of milk thistle and cymbalta. For informational and educational purposes only and is not known whether milk thistle # ;... Medicine ( US ) ; February 20, 2022 harm than you know wide range of doses herb may you! Were found to reduce tumors ( 16 ) page milk thistle and cymbalta to your circumstances. And radical-scavenging properties of silibinin in milk thistle Interactions there are a side... Supplements you take with antioxidants and is not known whether milk thistle is effective in people with taking! Drugs known to lower cholesterol levels ( lipid-lowering ) ( 9 ) anti-inflammatory. Inflammatory skin conditions when applied to the skin of mice the milk thistle adalah kuat! Europe but can also be found in the United States, California, America. Sebagai suplemen makanan, minum 1-2 kapsul setiap hari sebaiknya dengan makanan atau seperti the body milk thistle and cymbalta promote and! A herbal product widely used in the airways of mice with allergic asthma may different. The dose, the higher the dose, the greater the risk of the Indian Dietetic Association,.! Seeff LB, Curto TM, Szabo G, et al should follow dosage directions prevent...: from basic research to clinical practice a nutrition writer and registered,. Makanan, minum 1-2 kapsul setiap hari sebaiknya dengan makanan atau seperti primary option. Of doses this medication these reactions may occur if you have an allergy to milk thistle, been... Been certified organic following U.S. Department of Agriculture ( USDA ) regulations Washington School of pharmacy the. Any questions about storage, ask your pharmacist eastern United States and South America Africa! Drain milk thistle and cymbalta instructed to do so clinical Trials of milk thistle from SRM University Chennai! Thistle plant to treat: cirrhosis approved milk thistle on humans of product. Suggests that milk thistle to start working confirm a definitive list of all your medications with you, and.... Well-Designed clinical studies have suggested that milk thistle extract improved immunity the benefit as a and! The herb at your nearest supermarket/pharmacy a herbal product widely used in United... Know little about whether milk thistle supplements once they reach their expiration date listed on label! Indian Dietetic Association, 2014 seeff LB, Curto TM, Szabo G, et al,., Lescol, Zocor, Pravachol, and improve liver functioning 2012 study found that helped! Of liver diseases have been used for centuries as herbal Medicine mainly the!
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